POOL THROMBOZYENLYSAT

Ausgangsmaterial in der Arzneimittelherstellung

Pool-Thrombozytenlysat (PTL) zur Arzneimittelherstellung, clinical grade (GMP)

• Humanes Zellkultursupplement zur Expansion mesenchymaler Stammzellen (MSC) und anderer Zellarten – die anwenderfreundliche 2 in 1-Lösung

• Geeignet als Ausgangsstoff Ausgangsstoff.pdf] zur Arzneimittelherstellung (z.B. für Zelltherapeutika)

• Maximale Sicherheit

• Hohe Chargenhomogenität

• Kontrollierte Qualität

• Anwendungsgerechte Abpackung

 

Internationale Publikationen zum Thrombozythenlysat:

  • Shih DT, Burnouf T. Preparation, quality criteria, and properties of human blood hPL supplements for ex vivo stem cell expansion. N Biotechnol. 2015 Jan 25;32(1):199-211
  • Hofbauer P, Riedl S, Witzeneder K et al.Human platelet lysate is a feasible candidate to replace fetal calf serum as medium supplement for blood vascular and lymphatic endothelial cells. Cytotherapy. 2014 Sep;16(9):1238-44.
  • Hemeda H, Giebel B, Wagner W. Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells. Cytotherapy. 2014 Feb;16(2):170-180.
  • Ruggiu A, Ulivi V, Sanguineti F, et al. The effect of Platelet Lysate on osteoblast proliferation associated with a transient increase of the inflammatory response in bone regeneration. Biomaterials. 2013 Dec;34(37):9318-30 T
  • Barsotti MC, Losi P, Briganti E, et al. Effect of platelet lysate on human cells involved in different phases of wound healing. PLoS One. 2013 Dec 27;8(12):e84753.
  • Bieback K. Platelet lysate as replacement for fetal bovine serum in mesenchymal stromal cell cultures. Transfus Med Hemother. 2013 Oct;40(5):326-35.
  • Hemeda H, Kalz J, Walenda G, et al.Heparin concentration is critical for cell culture with human platelet lysate. Cytotherapy. 2013 Sep;15(9):1174-81.
  • Trojahn Kolle SF, Oliveri RS, Glovinski PV, et al. Pooled human platelet lysate versus fetal bovine serum-investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use. Cytotherapy. 2013 Sep;15(9):1086-1097.
  • Kinzebach S, Bieback K. Expansion of Mesenchymal Stem/Stromal cells under xenogenic-free culture conditions. Adv Biochem Eng Biotechnol. 2013;129:33-57.
  • Fekete N, Gadelorge M, Fürst D, et al.Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components. Cytotherapy. 2012 May;14(5):540-554.
  • Naaijkens BA, Niessen HW, Prins HJ, et al.Human platelet lysate as a fetal bovine serum substitute improves human adipose-derived stromal cell culture for future cardiac repair applications. Cell Tissue Res. 2012 Apr;348(1):119-130.
  • Jung S, Panchalingam KM, Wuerth RD, et al. Large-scale production of human mesenchymal stem cells for clinical applications. Biotechnol Appl Biochem. 2012 Mar-Apr; 59(2): 106-20.
  • Brindley DA, Davie NL, Culme-Seymour EJ, et al.Peak serum: implications of serum supply for cell therapy manufacturing. Regen Med. 2012 Jan;7(1):7-13.
  • Govindasmy V, Ronald VS, Abdullah AN, et al. Human platelet lysate permits scale-up of dental pulp stromal cells for clinical applications. Cytotherapy. 2011 Nov;13(10):1221-1233.
  • Castegnaro S, Chieregato K, Maddalena M, et al. Effect of platelet lysate on the functional and molecular characteristics of mesenchymal stem cells isolated from adipose tissue. Curr Stem Cell Res Ther. 2011 Jun;6(2):105-114.
  • Bernardo ME, Cometa AM, Pagliara D, et al. ex vivo expansion of mesenchymal stromal cells. Best Pract Res Clin Haematol. 2011 Mar;24(1):73-81.
  • Bieback K, Hecker A, Kocaömer A, et al. Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow. Stem Cells. 2009 Sep;27(9):2331-2341.
  • Schallmoser K., Bartmann C, Rohde E, et al.Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion. 2007 Aug;47(8):1436-46.
  • Doucet C, Ernou I, Zhang Y, et al. Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J Cell Physiol. 2005 Nov;205(2):228-236.

 

 

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